PE-22-28 8mg

PE-22-28 8mg

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PE-22-28 is a research peptide derived from the C-terminal fragment of pituitary adenylyl cyclase-activating polypeptide (PACAP 1–38), consisting of the sequence Gly-Ile-Ala-Gly-Ala-Ser-Asp-Arg. Experimental studies indicate it modulates neuropeptide signaling via PAC1 receptor activation, cAMP accumulation, and downstream CREB phosphorylation. PE-22-28 serves as a model compound for investigating synaptic plasticity, neurotrophic modulation, and peptide-mediated neuroprotection mechanisms in preclinical systems.

For research use only. Not for human consumption.

References:
Harmar AJ et al., Pharmacol Rev, 2012;64(4):990–1033
Ohtaki H et al., Regul Pept, 1998;77(1–3):73–80
Waschek JA et al., J Mol Neurosci, 1998;11(1):21–29

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Properties
Molecular Formula C35H55N11O9
Molecular Weight 773.9
Monoisotopic Mass 773.41842237
Polar Area 338
Complexity 1360
XLogP -3.7
Heavy Atom Count 55
Hydrogen Bond Donor Count 12
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 23
PubChem LCSS L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl- Laboratory Chemical Safety Summary
Identifiers
CID 165437303
InChI InChI=1S/C35H55N11O9/c1-18(2)12-24(31(51)43-23(34(54)55)10-7-11-39-35(37)38)42-28(49)16-41-30(50)25(13-20-15-40-22-9-6-5-8-21(20)22)44-32(52)26(17-47)45-33(53)29(19(3)4)46-27(48)14-36/h5-6,8-9,15,18-19,23-26,29,40,47H,7,10-14,16-17,36H2,1-4H3,(H,41,50)(H,42,49)(H,43,51)(H,44,52)(H,45,53)(H,46,48)(H,54,55)(H4,37,38,39)/t23-,24-,25-,26-,29-/m0/s1
InChIKey CMNBQRXBBJQIOA-YIHYGEMESA-N
Isometric SMILES CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)CNC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)CN
Canonical SMILES CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)CNC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)CN
IUPAC Name (2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid

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